油墨直写打印纳米羟基磷灰石/聚乳酸复合材料：制备及性能研究

doi:10.3901/JME.2020.09.234

机械工程学报 ›› 2020, Vol. 56 ›› Issue (9): 234-242.doi: 10.3901/JME.2020.09.234

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油墨直写打印纳米羟基磷灰石/聚乳酸复合材料：制备及性能研究

林坷升¹, 刘洁¹, 刘方政¹, 康红磊², 李锋², 史玉升¹

1. 华中科技大学材料成形与模具技术国家重点实验室武汉 430074;
2. 华中科技大学同济医学院附属同济医院骨科武汉 430030

收稿日期:2019-07-18 修回日期:2019-12-22 出版日期:2020-05-05 发布日期:2020-05-29
通讯作者: 刘洁(通信作者),女,1972年出生,博士,副教授。主要研究方向为增材制造技术。E-mail:hustliuj@hust.edu.cn
作者简介:林坷升,男,1995年出生。主要研究方向为高分子的3D打印。E-mail:linkeshenghust@163.com
基金资助:
国家重点研发计划课题资助项目（2016YFB1101303）。

Preparation and Properties of Ink Direct Writing Nano-hydroxyapatite/Polylactic Acid Composite Materials

LIN Kesheng¹, LIU Jie¹, LIU Fangzheng¹, KANG Honglei², LI Feng², SHI Yusheng¹

1. State key Laboratory of Materials Processing and Die & Mould Technology, Huazhong University of Science and Technology, Wuhan 430074;
2. Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030

Received:2019-07-18 Revised:2019-12-22 Online:2020-05-05 Published:2020-05-29

摘要/Abstract

摘要： 油墨直写打印（Direct ink writing，DIW）是一种基于浆料挤出的增材制造技术，其操作简单，成本低，可用于生物支架的制备和成形。本试验通过在纳米羟基磷灰石/聚乳酸（HA/PLA）的复合材料中添加10%海藻酸钠（Alg）作交联剂以支撑成形件，并对复合材料及DIW成形件的物理、化学、生物学性能进行了评价。结果表明：DIW成形件的最佳后处理温度80℃，拉伸试样的伸长率为0.06%，拉伸强度为0.5 MPa。复合材料在DIW打印成形和后处理过程后仍然具有PLA和HA材料的良好生物相容性和骨诱导性。在细胞毒性试验中，DIW成形件和压片成形件的细胞数量均呈现显著增长趋势，表现为无明显毒性。由此证明油墨直写打印成形此生物可降解材料是可行的，后续可进行优化提高DIW成形件的机械性能。

关键词: 油墨直写打印(DIW), 纳米羟基磷灰石(nano-HA), 聚乳酸(PLA), 生物可降解材料

Abstract: Direct ink writing is an additive manufacturing technology based on slurry extrusion. It is easy to operate and low-cost, and can be used in the preparation and forming of biological scaffolds. 10% Alg is added to HA/PLA composites as a crosslinking agent to support the DIW parts, and then the physical, chemical and biological properties of the composites and the DIW parts are evaluated. The results show that the optimal post-treatment temperature of the DIW part is 80℃, the elongation of the tensile specimen is 0.06%, and the tensile strength is 0.5 MPa. The composite material still had good biocompatibility and osteoinductivity of PLA and HA after the DIW process and post-treatment processes. In the cytotoxicity experiment, the number of cells in the DIW parts and tablet-formed parts exhibited a significant growth trend which indicated no obvious toxicity. It is demonstrated that it is feasible to form this biodegradable material by direct ink writing. And the mechanical properties of the DIW parts can be improved through some optimization at a later stage.

Key words: direct ink printing (DIW), nano-hydroxyapatite (nano-HA), polylactic acid (PLA), biodegradable material

中图分类号:

TB332
TB324

林坷升, 刘洁, 刘方政, 康红磊, 李锋, 史玉升. 油墨直写打印纳米羟基磷灰石/聚乳酸复合材料：制备及性能研究[J]. 机械工程学报, 2020, 56(9): 234-242.

LIN Kesheng, LIU Jie, LIU Fangzheng, KANG Honglei, LI Feng, SHI Yusheng. Preparation and Properties of Ink Direct Writing Nano-hydroxyapatite/Polylactic Acid Composite Materials[J]. Journal of Mechanical Engineering, 2020, 56(9): 234-242.

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油墨直写打印纳米羟基磷灰石/聚乳酸复合材料：制备及性能研究

Preparation and Properties of Ink Direct Writing Nano-hydroxyapatite/Polylactic Acid Composite Materials

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