Construction and Application of 3D Printer with Solenoid Valve Micro-jet Function

doi:10.3901/JME.2022.23.262

Abstract

Abstract: 3D printing technology has been widely used in biomedicine, sensor manufacture and other fields. However, traditional 3D printers have a different application range due to their distinct working modes. It is difficult to be compatible with biological preparation and sensor preparation at the same time. Therefore, using the solenoid valve as the nozzle, a 3D printer with a unique working mode is independently designed and constructed, and the high-precision droplet distribution mode is applied to the printing of 3D structures. The effects of cylinder pressure, solenoid valve switching time and nozzle height on the print droplet diameter are studied, and the print quality of point, line, net and surface patterns is evaluated. The tissue-engineered skin with dermal papilla structure and an array flexible pressure sensor are prepared by the printer, and the cell activity of the tissue-engineered skin and the pressure-resistance conversion characteristics of the pressure sensor are tested. The results show that the diameter of droplets is positively correlated with cylinder pressure, nozzle opening time and nozzle height. The printing effect of 3D printer on point, line, net and surface patterns is ideal. It can be applied to the preparation of tissue-engineered skin with dermal papilla and flexible pressure sensor, respectively. The 3D printer combines the advantages of inkjet printer and extrusion printer, has good compatibility with printing ink, has the advantages of simple printing mode, fast printing speed and high forming quality, is of great significance to the research of tissue-engineered skin and flexible pressure sensor, and lays a foundation for the preparation of bionic skin with sensing function.

Key words: 3D printer, solenoid valve nozzle, tissue-engineered skin, flexible pressure sensor

CLC Number:

TS853

SANG Shengbo, SHEN Zhizhong, ZHOU Chuangang, SUN Lei, QUAN Long. Construction and Application of 3D Printer with Solenoid Valve Micro-jet Function[J]. Journal of Mechanical Engineering, 2022, 58(23): 262-270.

References

[1] YOO S S,POLIO S. 3D on-demand bioprinting for the creation of engineered tissues[J]. Cell and Organ Printing,2010:3-19.
[2] 王锦阳,黄文华. 生物3D打印的研究进展[J]. 分子影像学杂志,2016,39(1):44-46.WANG Jinyang,HUANG Wenhua. Research status and application of 3D bio-printing[J]. Journal of Molecular Imaging,2016,39(1):44-46.
[3] PEI Z,ZHANG Q,LI Q,et al. A fully 3D printed electronic skin with bionic high resolution and air permeable porous structure[J]. Journal of Colloid and Interface Science,2021,602(48):452-458.
[4] LIU C,HUANG N,XU F,et al. 3D printing technologies for flexible tactile sensors toward wearable electronics and electronic skin[J]. Polymers,2018,10(6):629.
[5] KHOSRAVANI M R,REINICKE T. 3D-printed sensors:Current progress and future challenges[J]. Sensors and Actuators A:Physical,2020,305:111916.
[6] YANG H,LEOW W R,CHEN X D. 3D printing of flexible electronic devices[J]. Small Methods,2018,2(1):1700259.
[7] 吴春亚,吴佳昊,吴喆冉,等. 生物3D打印技术的新研究进展[J]. 机械工程学报,2021,57(5):114-132.WU Chunya,WU Jiahao,WU Zheran,et al. New progress of biological 3D printing technology[J]. Journal of Mechanical Engineering,2021,57(5):114-132.
[8] FENG P,WU P,GAO C D,et al. A multimaterial scaffold with tunable properties:Toward bone tissue repair[J]. Advanced Science,2018,5(6):1700817.
[9] CAO Y,YANG S B,ZHAO D Y,et al. Three-dimensional printed multiphasic scaffolds with stratified cell-laden gelatin methacrylate hydrogels for biomimetic tendon-to-bone interface engineering[J]. Journal of Orthopaedic Translation,2020,23:89-100.
[10] WANG Z J,ABDULLA R,PARKER B,et al. A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks[J]. Biofabrication,2015,7(4):045009.
[11] 叶淑源,周习远,苑景坤,等. 高速连续光固化3D打印工艺与树脂打印件性能研究[J]. 机械工程学报,2021,57(15):255-263.YE Shuyuan,ZHOU Xiyuan,YUAN Jingkun,et al. Study on high-speed continuous photopolymerizationg 3D printing process and properties of printed resin parts[J]. Journal of Mechanical Engineering,2021,57(15):255-263.
[12] YANG Y W,CHENG Y,PENG S P,et al. Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold[J]. Bioactive Materials,2021,6(5):1230-1241.
[13] TARASSOLI S P,JESSOP Z M,AL-SABAH A,et al. Skin tissue engineering using 3D bioprinting:An evolving research field[J]. Journal of Plastic Reconstructive & Aesthetic Surgery,2018,71(5):615-623.
[14] SINGH D,SINGH D,HAN S S. 3D printing of scaffold for cells delivery:Advances in skin tissue engineering[J]. Polymers(Basel),2016,8(1):19.
[15] 刘煜凡,黄沙,姚斌,等. 3D生物打印的微结构促进小鼠表皮干细胞的增殖和活性[J]. 南方医科大学学报,2017,37(6):761-766.LIU Yufan,HUANG Sha,YAO Bin,et al. Three-dimensional bioprinted microstructure promotes proliferation and viability of murine epithelial stem cells in vitro[J]. Journal of Southern Medical University,2017,37(6):761-766.
[16] SHEN Z Z,CAO Y Y,LI M,et al. Construction of tissue-engineered skin with rete ridges using co-network hydrogels of gelatin methacrylated and poly(ethylene glycol) diacrylate[J]. Materials Science and Engineering:C,2021,129:112360.
[17] RAMOS-RODRIGUEZ D H,MACNEIL S,CLAEYSSENS F,et al. Fabrication of topographically controlled electrospun scaffolds to mimic the stem cell microenvironment in the dermal-epidermal junction[J]. ACS Biomaterials Sciejnce and Engineering,2021,7(6):2803-2813.
[18] ROIG-ROSELLO E,ROUSSELLE P. The human epidermal basement membrane:A shaped and cell instructive platform that aging slowly alters[J]. Biomolecules,2020,10(12):1607.
[19] NIEHUES H,BOUWSTRA J A,EI GHALBZOURI A,et al. 3D skin models for 3R research:The potential of 3D reconstructed skin models to study skin barrier function[J]. Experimental Dermatology,2018,27(5):501-511.
[20] BARROS N R,KIM H J,GOUDIE M J,et al. Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering[J]. Biofabrication,2021,13(3):035030.
[21] KIM B S,LEE J S,GAO G,et al. Direct 3D cell-printing of human skin with functional transwell system[J]. Biofabrication,2017,9(2):025034.
[22] SHIH B,SHAH D,LI J X,et al. Electronic skins and machine learning for intelligent soft robots[J]. Science Robotics,2020,5(41):9239.
[23] DAHIYA A S,KUMARESAN Y,OZIOKO O,et al. Soft sensors for electronic skin[J]. Reference Module in Biomedical Sciences,2021.
[24] BABA H,YOSHIDA M,YOKOTA T,et al. Human epidermal basal cell responses to ultraviolet-B differ according to their location in the undulating epidermis[J]. Journal of Dermatological Science,2005,38(1):41-46.
[25] LANGTON A K,SHERRATT M J,SELLERS W I,et al. Geographical ancestry is a key determinant of epidermal morphology and dermal composition[J]. British Journal of Dermatology,2014,171(2):274-282.