多孔β-TCP生物陶瓷DLP打印工艺研究

doi:10.3901/JME.2019.15.081

机械工程学报 ›› 2019, Vol. 55 ›› Issue (15): 81-87.doi: 10.3901/JME.2019.15.081

• 特邀专栏：增材制造技术 • 上一篇下一篇

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多孔β-TCP生物陶瓷DLP打印工艺研究

张航¹, 许宋锋², 熊胤泽¹, 高芮宁¹, 李祥

1. 上海交通大学机械系统与振动国家重点实验室上海 200240;
2. 国家癌症中心\国家肿瘤临床医学研究中心\中国医学科学院北京协和医学院肿瘤医院骨科北京 100021

收稿日期:2018-11-14 修回日期:2019-02-16 出版日期:2019-08-05 发布日期:2019-08-05
通讯作者: 李祥(通信作者),男,1978年出生,博士,副研究员,博士研究生导师。主要研究方向为增材制造技术及应用。E-mail:xiangliwj@sjtu.edu.cn
作者简介:张航,男,1994年出生,博士研究生。主要研究方向为生物陶瓷3D打印。E-mail:hangzhang@sjtu.edu.cn;许宋锋,男,1977年出生,博士,副主任医师。主要研究方向为骨与软组织肿瘤。
基金资助:
国家自然科学基金（51475293）、上海张江国家自主创新示范区专项发展资金重点（201701-PD-JQ-C1085-012）和协和青年科研基金（2017320016）资助项目。

Fabrication of Porous β-TCP Bioceramics Using Digital Light Processing

ZHANG Hang¹, XU Songfeng², XIONG Yinze¹, GAO Ruining¹, LI Xiang

1. State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai 200240;
2. National Cancer Center\National Cancer Clinical Medical Research Center\Chinese Academy of Medical Sciences, Peking Union Medical College, Department of Orthopaedics, Beijing 100021

Received:2018-11-14 Revised:2019-02-16 Online:2019-08-05 Published:2019-08-05

摘要/Abstract

摘要： β-磷酸三钙（β-TCP）具有良好的生物相容性和成骨性，是理想的骨修复材料。以β-TCP陶瓷粉末和树脂为原料制备陶瓷浆料，利用面曝光技术制造陶瓷素坯。根据热重和差热测试结果，建立陶瓷素坯脱脂和烧结工艺参数，制备出多孔β-TCP陶瓷样件。试验结果表明，成型过程中，光线散射会导致实际成型的素坯尺寸大于设计尺寸；烧结后，在成型的水平方向烧结收缩率为1%~5%，垂直方向烧结收缩率为6%~9%，并提出了烧结收缩的补偿模型。多孔陶瓷样件内部孔道结构贯通，具有大孔和微孔相结合的多孔结构，大孔孔径为400~600 μm，微孔孔径为500~1 500 nm。力学测试表明多孔结构的压缩强度随孔隙率的增大而减小，G单元多孔β-TCP生物陶瓷的压缩强度最高可达16.53 MPa。DLP光固化生物陶瓷打印技术可以实现复杂多孔生物陶瓷的快速高精度成型，在人体骨组织损伤修复方面有巨大的应用前景。

关键词: &beta, 多孔结构, -磷酸三钙, 数字光处理, 陶瓷打印

Abstract: Beta-tricalcium phosphate (β-TCP) is an ideal bone repair material with good biocompatibility and osteogenicity. A DLP-system used in this study creates bioceramic green part by stacking up layers of photocurable tricalcium phosphate-filled slurry with various TCP weight fraction. After a thermal debinding and sintering step, the part turns into a dense ceramic according to the results of thermogravimetric (TG) and differential scanning calorimetry (DSC). Results show that the actual ceramic green part size is larger than the design size because of light scattering. The sintering shrinkage in the horizontal direction is 1%-5%, and the sintering shrinkage in the building direction is 6%-9% after sintering. Thus, a compensation model for sintering shrinkage is proposed to obtain high-precision final TCP parts. The obtained porous TCP parts have both macroporous outer structure and microporous inner structure, the macropore size is 400-600μm and the micropore size is 500-1 500 nm. The mechanical tests show that the compressive strength of the porous β-TCP bioceramic is up to 16.53 MPa. DLP is a promising technology in human bone tissue damage repair which can rapidly printing porous structure in high-precision.

Key words: β-tricalcium phosphate, ceramic printing, digital light processing, porous structure

中图分类号:

TH164

张航, 许宋锋, 熊胤泽, 高芮宁, 李祥. 多孔β-TCP生物陶瓷DLP打印工艺研究[J]. 机械工程学报, 2019, 55(15): 81-87.

ZHANG Hang, XU Songfeng, XIONG Yinze, GAO Ruining, LI Xiang. Fabrication of Porous β-TCP Bioceramics Using Digital Light Processing[J]. Journal of Mechanical Engineering, 2019, 55(15): 81-87.

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多孔β-TCP生物陶瓷DLP打印工艺研究

Fabrication of Porous β-TCP Bioceramics Using Digital Light Processing

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