具有电磁阀微喷功能的3D打印机构建及应用

doi:10.3901/JME.2022.23.262

机械工程学报 ›› 2022, Vol. 58 ›› Issue (23): 262-270.doi: 10.3901/JME.2022.23.262

扫码分享

具有电磁阀微喷功能的3D打印机构建及应用

桑胜波¹, 申治中¹, 周传刚^1,2, 孙蕾¹, 权龙³

1. 太原理工大学微纳传感与人工智能感知山西省重点实验室太原 030024;
2. 山西省六维人工智能生物医学研究院太原 030031;
3. 太原理工大学机械与运载学院太原 030024

收稿日期:2022-03-07 修回日期:2022-07-22 出版日期:2022-12-05 发布日期:2023-02-08
通讯作者: 孙蕾(通信作者),女,1990年出生,博士,讲师。主要研究方向为微纳制造方法,3D微纳打印技术。E-mail:sunlei@tyut.edu.cn
作者简介:桑胜波,男,1979年出生,博士,教授。主要研究方向为传感与集成测试系统,微纳生物传感器,微纳生物再生技术。E-mail:sunboa-sang@tyut.edu.cn;权龙,男,1959年出生,博士,教授,博士研究生导师。主要研究方向为电液伺服及比例控制技术。E-mail:quanlong@tyut.edu.cn
基金资助:
国家自然科学基金(51975400，61703298)、国家重点研究发展计划(2019YFB1310200)和山西省优秀人才创新科技计划(201805D211020)资助项目。

Construction and Application of 3D Printer with Solenoid Valve Micro-jet Function

SANG Shengbo¹, SHEN Zhizhong¹, ZHOU Chuangang^1,2, SUN Lei¹, QUAN Long³

1. Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception, Taiyuan University of Technology, Taiyuan 030024;
2. Shanxi Institute of 6D Artificial Intelligence Biomedical Science, Taiyuan 030031;
3. College of Mechanical and Vehicle Engineering, Taiyuan University of Technology, Taiyuan 030024

Received:2022-03-07 Revised:2022-07-22 Online:2022-12-05 Published:2023-02-08

摘要/Abstract

摘要： 3D打印技术已经在生物医学、传感器制造等领域得到广泛应用。然而，传统3D打印机由于自身工作方式的不同，适用范围不同，难以同时兼容生物制备和传感器制备。因此，以电磁阀作为3D打印机的喷头，自主设计并构建具有独特工作方式的3D打印机，将高精度液滴分配方式应用于3D结构打印。研究料筒气压、电磁阀开关时间、喷头高度对打印液滴直径的影响，并对点、线、网、面图案的打印质量进行评估；利用所构建的打印机制备具有真皮乳头结构的组织工程皮肤和阵列式柔性压力传感器，测试组织工程皮肤的细胞活性及压力传感器的压-阻转换特性。结果表明，打印液滴直径尺寸与料筒气压、喷头开启时间、喷头高度均成正相关；3D打印机对点、线、网、面图案的打印效果较为理想；可成功应用于具有真皮乳头结构的组织工程皮肤和柔性压力传感器的制备。所构建的3D打印机融合喷墨式打印机和挤出式打印机的优势，对打印墨水有较好的兼容性，具有打印方式简单、打印速度快、成型质量高的优点，对组织工程皮肤及柔性压力传感器的研究具有重要意义，为实现具有感知功能仿生皮肤的制备奠定基础。

关键词: 3D打印机, 电磁阀喷头, 组织工程皮肤, 柔性压力传感器

Abstract: 3D printing technology has been widely used in biomedicine, sensor manufacture and other fields. However, traditional 3D printers have a different application range due to their distinct working modes. It is difficult to be compatible with biological preparation and sensor preparation at the same time. Therefore, using the solenoid valve as the nozzle, a 3D printer with a unique working mode is independently designed and constructed, and the high-precision droplet distribution mode is applied to the printing of 3D structures. The effects of cylinder pressure, solenoid valve switching time and nozzle height on the print droplet diameter are studied, and the print quality of point, line, net and surface patterns is evaluated. The tissue-engineered skin with dermal papilla structure and an array flexible pressure sensor are prepared by the printer, and the cell activity of the tissue-engineered skin and the pressure-resistance conversion characteristics of the pressure sensor are tested. The results show that the diameter of droplets is positively correlated with cylinder pressure, nozzle opening time and nozzle height. The printing effect of 3D printer on point, line, net and surface patterns is ideal. It can be applied to the preparation of tissue-engineered skin with dermal papilla and flexible pressure sensor, respectively. The 3D printer combines the advantages of inkjet printer and extrusion printer, has good compatibility with printing ink, has the advantages of simple printing mode, fast printing speed and high forming quality, is of great significance to the research of tissue-engineered skin and flexible pressure sensor, and lays a foundation for the preparation of bionic skin with sensing function.

Key words: 3D printer, solenoid valve nozzle, tissue-engineered skin, flexible pressure sensor

中图分类号:

TS853

桑胜波, 申治中, 周传刚, 孙蕾, 权龙. 具有电磁阀微喷功能的3D打印机构建及应用[J]. 机械工程学报, 2022, 58(23): 262-270.

SANG Shengbo, SHEN Zhizhong, ZHOU Chuangang, SUN Lei, QUAN Long. Construction and Application of 3D Printer with Solenoid Valve Micro-jet Function[J]. Journal of Mechanical Engineering, 2022, 58(23): 262-270.

参考文献

[1] YOO S S,POLIO S. 3D on-demand bioprinting for the creation of engineered tissues[J]. Cell and Organ Printing,2010:3-19.
[2] 王锦阳,黄文华. 生物3D打印的研究进展[J]. 分子影像学杂志,2016,39(1):44-46.WANG Jinyang,HUANG Wenhua. Research status and application of 3D bio-printing[J]. Journal of Molecular Imaging,2016,39(1):44-46.
[3] PEI Z,ZHANG Q,LI Q,et al. A fully 3D printed electronic skin with bionic high resolution and air permeable porous structure[J]. Journal of Colloid and Interface Science,2021,602(48):452-458.
[4] LIU C,HUANG N,XU F,et al. 3D printing technologies for flexible tactile sensors toward wearable electronics and electronic skin[J]. Polymers,2018,10(6):629.
[5] KHOSRAVANI M R,REINICKE T. 3D-printed sensors:Current progress and future challenges[J]. Sensors and Actuators A:Physical,2020,305:111916.
[6] YANG H,LEOW W R,CHEN X D. 3D printing of flexible electronic devices[J]. Small Methods,2018,2(1):1700259.
[7] 吴春亚,吴佳昊,吴喆冉,等. 生物3D打印技术的新研究进展[J]. 机械工程学报,2021,57(5):114-132.WU Chunya,WU Jiahao,WU Zheran,et al. New progress of biological 3D printing technology[J]. Journal of Mechanical Engineering,2021,57(5):114-132.
[8] FENG P,WU P,GAO C D,et al. A multimaterial scaffold with tunable properties:Toward bone tissue repair[J]. Advanced Science,2018,5(6):1700817.
[9] CAO Y,YANG S B,ZHAO D Y,et al. Three-dimensional printed multiphasic scaffolds with stratified cell-laden gelatin methacrylate hydrogels for biomimetic tendon-to-bone interface engineering[J]. Journal of Orthopaedic Translation,2020,23:89-100.
[10] WANG Z J,ABDULLA R,PARKER B,et al. A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks[J]. Biofabrication,2015,7(4):045009.
[11] 叶淑源,周习远,苑景坤,等. 高速连续光固化3D打印工艺与树脂打印件性能研究[J]. 机械工程学报,2021,57(15):255-263.YE Shuyuan,ZHOU Xiyuan,YUAN Jingkun,et al. Study on high-speed continuous photopolymerizationg 3D printing process and properties of printed resin parts[J]. Journal of Mechanical Engineering,2021,57(15):255-263.
[12] YANG Y W,CHENG Y,PENG S P,et al. Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold[J]. Bioactive Materials,2021,6(5):1230-1241.
[13] TARASSOLI S P,JESSOP Z M,AL-SABAH A,et al. Skin tissue engineering using 3D bioprinting:An evolving research field[J]. Journal of Plastic Reconstructive & Aesthetic Surgery,2018,71(5):615-623.
[14] SINGH D,SINGH D,HAN S S. 3D printing of scaffold for cells delivery:Advances in skin tissue engineering[J]. Polymers(Basel),2016,8(1):19.
[15] 刘煜凡,黄沙,姚斌,等. 3D生物打印的微结构促进小鼠表皮干细胞的增殖和活性[J]. 南方医科大学学报,2017,37(6):761-766.LIU Yufan,HUANG Sha,YAO Bin,et al. Three-dimensional bioprinted microstructure promotes proliferation and viability of murine epithelial stem cells in vitro[J]. Journal of Southern Medical University,2017,37(6):761-766.
[16] SHEN Z Z,CAO Y Y,LI M,et al. Construction of tissue-engineered skin with rete ridges using co-network hydrogels of gelatin methacrylated and poly(ethylene glycol) diacrylate[J]. Materials Science and Engineering:C,2021,129:112360.
[17] RAMOS-RODRIGUEZ D H,MACNEIL S,CLAEYSSENS F,et al. Fabrication of topographically controlled electrospun scaffolds to mimic the stem cell microenvironment in the dermal-epidermal junction[J]. ACS Biomaterials Sciejnce and Engineering,2021,7(6):2803-2813.
[18] ROIG-ROSELLO E,ROUSSELLE P. The human epidermal basement membrane:A shaped and cell instructive platform that aging slowly alters[J]. Biomolecules,2020,10(12):1607.
[19] NIEHUES H,BOUWSTRA J A,EI GHALBZOURI A,et al. 3D skin models for 3R research:The potential of 3D reconstructed skin models to study skin barrier function[J]. Experimental Dermatology,2018,27(5):501-511.
[20] BARROS N R,KIM H J,GOUDIE M J,et al. Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering[J]. Biofabrication,2021,13(3):035030.
[21] KIM B S,LEE J S,GAO G,et al. Direct 3D cell-printing of human skin with functional transwell system[J]. Biofabrication,2017,9(2):025034.
[22] SHIH B,SHAH D,LI J X,et al. Electronic skins and machine learning for intelligent soft robots[J]. Science Robotics,2020,5(41):9239.
[23] DAHIYA A S,KUMARESAN Y,OZIOKO O,et al. Soft sensors for electronic skin[J]. Reference Module in Biomedical Sciences,2021.
[24] BABA H,YOSHIDA M,YOKOTA T,et al. Human epidermal basal cell responses to ultraviolet-B differ according to their location in the undulating epidermis[J]. Journal of Dermatological Science,2005,38(1):41-46.
[25] LANGTON A K,SHERRATT M J,SELLERS W I,et al. Geographical ancestry is a key determinant of epidermal morphology and dermal composition[J]. British Journal of Dermatology,2014,171(2):274-282.

具有电磁阀微喷功能的3D打印机构建及应用

Construction and Application of 3D Printer with Solenoid Valve Micro-jet Function

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 3

编辑推荐

Metrics

本文评价

[1]	赵家浩, 黄汉雄. 微乳突提高低力学刺激下微结构柔性压力传感器的性能[J]. 机械工程学报, 2024, 60(4): 222-229.
[2]	罗毅辉, 彭倩倩, 朱宇超, 王广顺, 吴德志, 朱睿, 谢瑜, 孙道恒. 喷印柔性压力传感器试验研究[J]. 机械工程学报, 2019, 55(11): 90-97.
[3]	常定勇, 方跃法, 叶伟. 双输出3D打印解耦并联机器人的设计与分析^*[J]. 机械工程学报, 2017, 53(7): 39-46.