• CN: 11-2187/TH
  • ISSN: 0577-6686

Journal of Mechanical Engineering ›› 2023, Vol. 59 ›› Issue (19): 237-252.doi: 10.3901/JME.2023.19.237

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Advances in 3D Bioprinting: Additive Manufacturing of Living Cells from Animal, Plant, and Microbe

LI Peixi1,2, ZHOU Dezhi1, YANG Changming1, RAO Weiyi1,3, LIN Feng1, OUYANG Liliang1   

  1. 1. Department of Mechanical Engineering, Tsinghua University, Beijing 100084;
    2. Weiyang College, Tsinghua University, Beijing 100084;
    3. Tanwei College, Tsinghua University, Beijing 100084
  • Received:2023-03-01 Revised:2023-08-25 Online:2023-10-05 Published:2023-12-11

Abstract: The bionic manufacturing of biological organisms is of great significance to the exploration and exploitation of life mechanisms. Based on computer-aided design and control, 3D bioprinting can spatially manipulate living cells, biomaterials, biochemical factors, and other substances. It can produce biological tissue constructs that mimic the structural complexity and component heterogeneity of native tissues for fundamental research in life science and clinical translation in medicine. In recent years, 3D bioprinting technology has also been used in plant cell culture and microbial synthesis with great potential. This paper will introduce the basic principles and recent advances of 3D bioprinting technologies, and overview the applications of bioprinting animal, plant, and microbial cells by providing the most recent examples. This paper will also discuss the challenges and opportunities and aims to provide a vision for the trends in the field.

Key words: 3D bioprinting, animal cell printing, plant cell printing, microbial cell printing

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