Abstract: A fabrication system for artificial bioactive bone manufacturing is set up. The artificial bone constructed in this system has the exact external form of the replaced bone and a 3D scaffold simulating the microvaso system of bone tissue in the interior. Through attaching the skeletal growth factor and viable cells to the 3D scaffold, the artificial bone can attain bioactivity. This approach can improve the traditional method that cannot realize osteoinduction because the filling biomaterial has not activity. The animal experiment results show that the interior simulation structures of the Volkmann's canal and Haversian canal can provide proper space for the 3D growth of the osteocyte and quick activation of the artificial bone, and hence can effectively speed up the quick activation of the artificial bone.

Key words: Artificial bone, Bioactive, Rapid prototyping