Abstract: The mechanisms of cell adhesion on rough surface are introduced in detail, the effects of various roughness of Ti-material surface on cell adhesion and the models of effects of surface roughness on cell adhesion are summarized and analyzed comprehensively by taking into consideration surface processing methods. The summary shows that the rough surface promotes cell adhesion by altering surface force field, surface charge and surface energy, increasing specific surface area and surface defect etc. The surface roughness of Ti-material has different effect on adhesion of different cell types, and the rough surface promotes the expression of cell genes. Because surface processing can change the surface chemistry and affect surface charge and energy, surface processing methods should be taken into account in order to design the implant surface morphology with the proper surface roughness for cell adhesion. Moreover, the method of molecular dynamics simulation for cell adsorption on titanium surface is explored, which shows that the effect mechanisms of surface characteristics on protein and cell adhesion on titanium surface can be studied through molecular dynamics simulation at the molecule level.

Key words: Biomolecular dynamics simulation, Cell adhesion, Surface roughness, Ti-material for biomedical applications