Design of Microcavity Capsule Structures for Glioma Radiochemotherapy and Study on Dose Distribution and Dynamic Response

doi:10.3901/JME.260386

Abstract

Abstract: To address the challenges in glioma radiotherapy, including difficulties in controlling drug dosage, uneven radiation dose distribution, poor outcomes from single treatment, and high risks of repeated surgeries, a novel glioma radiochemotherapy microcavity capsule is designed to achieve full coverage irradiation of the tumor. First, Monte Carlo simulation software GEANT4 is used to calculate the radiation dose distribution of the microcavity capsule in a water phantom, analyzing radial dose and anisotropy at different angles and exploring the three-dimensional dose distribution to investigate the dosimetric characteristics of the structure. Then, finite element simulation is employed to analyze the dynamic response of the microcavity capsule structure, assessing its feasibility and safety for clinical application. Finally, LiF thermoluminescent dosimeters are used to experimentally measure and validate the radiation dose distribution in the water phantom. The Monte Carlo dose distribution simulation results showed that the surface absorbed dose rate of the microcavity capsule is high. As the radial distance increased, the absorbed dose rate rapidly decreased in all directions. Additionally, due to the influence of its shape, the absorbed dose rate exhibited a spiral distribution. The finite element simulation results indicated that the maximum stress and displacement of the implanted microcavity capsule fluctuated cyclically under total physiological load, with a maximum stress of 0.422 MPa and a maximum displacement of 0.272 mm per cycle. When the maximum stress is less than 6 MPa, the deformation remained below 15% of the capsule's length, meeting safety requirements for intracranial irradiation. Experimental validation results showed good agreement between the simulation and measured data, demonstrating that the microcavity capsule can provide long-term, stable low-dose irradiation, enabling localized high-dose radiotherapy.

Key words: glioma radiochemotherapy, microcavitary capsule, structural design, radiation dose distribution, dynamic response, finite element simulation

CLC Number:

TL72

LI Dongjie, LIANG Yu, YAO Gang, GAO Weida, RONG Weibin, YANG Liu, ZHANG Yu. Design of Microcavity Capsule Structures for Glioma Radiochemotherapy and Study on Dose Distribution and Dynamic Response[J]. Journal of Mechanical Engineering, 2026, 62(7): 405-417.

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URL: http://www.cjmenet.com.cn/EN/10.3901/JME.260386

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