组织工程骨支架内部微孔结构流场特性分析

doi:10.3901/JME.2018.20.071

机械工程学报 ›› 2018, Vol. 54 ›› Issue (20): 71-80.doi: 10.3901/JME.2018.20.071

组织工程骨支架内部微孔结构流场特性分析

杨立军, 张佳, 王哲, 闫程程

陕西科技大学生物材料与仿生制造研究所西安 710021

收稿日期:2017-09-20 修回日期:2018-06-23 出版日期:2018-10-20 发布日期:2018-10-20
通讯作者: 张佳(通信作者),男,1992年出生,硕士研究生。主要研究方向为组织工程骨支架仿生设计与优化。E-mail:806148187@qq.com
作者简介:杨立军,男,1974年出生,博士,教授,硕士研究生导师。主要研究方向为数字化逆向工程与仿生制造技术、3D打印技术及其设备研究和机械CAD/CAM/CAE技术。E-mail:yanglijun@sust.edu.cn
基金资助:
国家自然科学基金（50972086）、陕西省教育厅专项（11JK0861）和陕西省自然科学基础研究计划（2018JM5012）资助项目。

Analysis of the Flow Field Characteristics of Micro-pore Structure in Tissue Engineering Scaffold

YANG Lijun, ZHANG Jia, WANG Zhe, YAN Chengcheng

Institute of Biomaterials and Bionic Manufacturing, Shaanxi University of Science and Technology, Xi'an 710021

Received:2017-09-20 Revised:2018-06-23 Online:2018-10-20 Published:2018-10-20

摘要/Abstract

摘要： 组织工程骨支架内部微孔结构对于营养液的渗入和细胞的长入有着至关重要的影响，也直接关系到支架是否能够代替缺损部位的骨骼，继续发挥其作用与功能。根据骨骼内部微孔结构的扫描电镜形貌设计三种微孔单胞模型，并利用ADINA有限元分析软件对组织工程骨支架微孔单胞模型内营养液的流动性能进行了数值模拟，得到不同类型微孔单胞模型内部流场的压力和速度分布，分析模型参数对营养液平均入口压力和流速的影响规律。结果表明：当营养液从微孔单胞模型的上端流入到下端流出时，最大压力均出现在入口部位且靠近单胞模型壁面处，营养液流速变化趋势是先增大后减少，且最大流速均出现在入口附近。随着连通孔径的增大，平均入口压力值减少，营养液流速值更大，且分布更均匀。对于带孔板-杆单胞和带孔板单胞而言，与连通孔径D相比，中心孔径D_s对平均入口压力和流速的影响很小。通过对比不同类型单胞模型，发现开口杆状单胞模型的平均入口压力更稳定，压力值更小，处于（0.300~0.412）Pa，且营养液流速更大，分布更均匀，且最大流速处于（0.011 8~0.013 1）m/s，更有利于营养液快速均匀渗入和细胞均匀的沉积。所取得的研究结果对组织工程骨支架内部微孔结构的优化设计、后续仿形建模的研究及快速成型制造奠定了基础。

关键词: 单胞模型, 流动性能, 数值模拟, 组织工程骨支架

Abstract: The micro-pore structure of tissue engineering scaffold has a great influence on the flow of nutrient liquid and ingrowth of cell, it also directly affects whether the scaffold can replace the bone in the defect site, and continues to function. According to the SEM morphology of the internal structure in natural bone, three kinds of basic unit cells are designed. The flow property of nutrient solution in the scaffold is numerically simulated by using the finite element analysis software ADINA. The pressure and velocity distribution in different types of basic unit cells are obtained, and the influence of the model parameters on the average inlet pressure and velocity of nutrient solution is also analyzed. The results show that when nutrient solution flows from the upper face of the basic unit cells to the lower face, the maximum pressure appeared at the upper face and near the unit cell wall, the velocity increases first and then reduces, and the maximum velocity appears near the entrance. With the increase of pore diameter, the average inlet pressure decreases, the nutrient solution velocity increases, and its distribution becomes more uniform. As for hole plate-rod unit cell and hole plate unit cell, compared with connected aperture D, the effect of central aperture D_s on the average inlet pressure and flow velocity is small. By comparing the different types of basic unit cells, it is found that open rod unit cell shows a more stable and smaller average inlet pressure, its value is (0.300 to 0.412) Pa and the internal nutrient solution flows faster and more uniform, the maximum flow rate is (0.011 8 to 0.013 1) m/s. It is more beneficial to the growth of nutrient solution and cells. Results obtained in this study laid the foundation for the optimal design of the structure, research on profile modeling and rapid prototyping of bone scaffold.

Key words: basic unit cell, flow property, numerical simulation, tissue engineering scaffold

中图分类号:

TH16

杨立军, 张佳, 王哲, 闫程程. 组织工程骨支架内部微孔结构流场特性分析[J]. 机械工程学报, 2018, 54(20): 71-80.

YANG Lijun, ZHANG Jia, WANG Zhe, YAN Chengcheng. Analysis of the Flow Field Characteristics of Micro-pore Structure in Tissue Engineering Scaffold[J]. Journal of Mechanical Engineering, 2018, 54(20): 71-80.

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组织工程骨支架内部微孔结构流场特性分析

Analysis of the Flow Field Characteristics of Micro-pore Structure in Tissue Engineering Scaffold

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