含微通道网络的再生支架3D打印成形工艺和系统及试验研究

doi:10.3901/JME.2015.21.137

摘要/Abstract

摘要：

3D打印技术在构建个性化的人工组织和器官方面具有独特优势和发展潜力，然而目前在构建具有优良代谢性能的人工组织方面也还存在很多技术壁垒。在秉承3D打印技术优势基础上，综合考虑生物材料的反应成形特性，提出一种能够直接成形微尺度中空纤维，再三维叠层制造，从而直接获得内含微通道网络的再生支架的3D打印成形工艺；基于管材无模拉伸理论，定量分析微尺度中空纤维在被三维搭接过程中的拉伸变形，为工艺优化和参数调控奠定了理论基础；在给出相应成形系统的关键组成和技术要点基础上，进行了三维再生支架的制备试验及性能测试与分析。试验结果表明，提出的工艺及系统存在巨大的应用潜力，为有效解决人工再生组织血管化问题提供了一种全新的技术途径。

关键词: 微通道网络, 再生支架

font-size: 9pt, layout-grid-mode: char, margin: 0cm 0cm 0pt, mso-ascii-font-family: 'Times New Roman', mso-bidi-font-size: 10.5pt" lang="EN-US">, mso-bidi-font-weight: bold, mso-hansi-font-family: 'Times New Roman'">打印成形工艺, mso-layout-grid-align: none" class="MsoNormal">3D3D printing technology has unique advantages and potential in the fabrication of artificial tissues and organs. However, there are still technological barriers in building artificial tissues with good metabolic performance. Based on the advantages of 3D printing technology, and adopting the features of the reaction forming of biomaterials, a new 3D printing process is proposed, in which hollow fibers can be formed directly, thus leading to the successful fabricating of the scaffolds containing microchannel network through three dimensional laminated manufacturing. By using dieless drawing theory, the deformation of hollow fiber size caused as a consequence of the drawing during the process of fabricating scaffold is quantitatively analyzed, which will then lays a well theoretical foundation for process optimization and parameter control. Besides, after the explaining of the key components and techniques for constructing the new 3D printing system, the experiments for fabricating, testing and analyzing scaffolds are then proceeded. The results show that the proposed new 3D printing process and system have good application potentials, and will surely provide a new technological approach for effectively solving the vascularization problem of artificial regenerated tissues.

Key words: microchannel network, regeneration scaffolds, 3D printing forming process

刘媛媛, 梁刚, 李瑜, 张亚男, 李帅, 胡庆夕. 含微通道网络的再生支架3D打印成形工艺和系统及试验研究[J]. 机械工程学报, doi: 10.3901/JME.2015.21.137.

LIU Yuanyuan, LIANG Gang, LI Yu, ZHANG Yanan, LI Shuai, HU Qingxi.

The 3D Printing Process and Forming System for Regenerated Scaffold Containing Microchannel Network and the Experimental Research

[J]. Journal of Mechanical Engineering, doi: 10.3901/JME.2015.21.137.

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