• CN: 11-2187/TH
  • ISSN: 0577-6686

Journal of Mechanical Engineering ›› 2018, Vol. 54 ›› Issue (20): 64-70.doi: 10.3901/JME.2018.20.064

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Design and Application of High-precision Quantitative Spectroscopic Photoacoustic Imaging System

YAN Kang1,2, ZHANG Jianhui1,3, ZHANG Fan2,3, ZHOU Yingzi2,4, GONG Xiaojing2   

  1. 1. State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016;
    2. Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055;
    3. School of Mechanical and Electric Engineering, Guangzhou University, Guangzhou 510006;
    4. College of Electrical and Information Engineering, Hunan University, Changsha 410000
  • Received:2017-11-15 Revised:2018-01-03 Online:2018-10-20 Published:2018-10-20

Abstract: Rupture of coronary plaque is the main cause of acute cardiovascular events. For the diagnosis of plaque vulnerability, not only its morphological characteristics, but plaque components (such as lipids), and its concentration distribution are crucial information. In response to this demand, a high precise spectroscopic photoacoustic imaging system has been developed, which is capable for the plaque components identify, separation, concentration quantitative analysis and imaging. Compared with previous studies, the signal-to-noise ratio of the system is improved by the design of confocally optical excitation and ultrasonic detection with transmission mode, which increase the accuracy of photoacoustic spectroscopy data dramatically. And the certainty of correspondence between photoacoustic spectroscopy and its spatial sources is ensured by scanning wavelength before moving sample. The spectral separation and quantitative analysis of each components are achieved by multivariate curve resolution. The efficient of the system is validated by phantom and animal models experiments, in which the distribution of lipid concentration are mapped with high accuracy. The proposed spectroscopic photoacoustic imaging system shows the potential to narrow the gap for clinical translation.

Key words: atherosclerosis, multivariate curve resolution, photoacoustic spectroscopy, quantitative analysis, spectroscopic imaging

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