颅骨组织工程血管支架的参数化设计

doi:10.3901/JME.2018.01.178

机械工程学报 ›› 2018, Vol. 54 ›› Issue (1): 178-187.doi: 10.3901/JME.2018.01.178

颅骨组织工程血管支架的参数化设计

刘洁, 郑淑贤, 李佳

天津大学装备设计与制造技术天津市重点实验室天津 300354

收稿日期:2017-02-13 修回日期:2017-08-05 出版日期:2018-01-05 发布日期:2018-01-05
通讯作者: 郑淑贤(通信作者),女,1976年出生,博士,副教授。主要研究方向机械CAD/CAM、生物制造。E-mail:sxzheng@tju.edu.cn
作者简介:刘洁,女,1990年出生。主要研究方向为机械CAD/CAM。E-mail:ljlqq@tju.edu.cn
基金资助:
国家自然科学基金资助项目（51575380）。

Parametric Design for Skull Tissue Engineering Vascular Scaffold

LIU Jie, ZHENG Shuxian, LI Jia

Tianjin Key Laboratory of Equipment Design and Manufacturing Technology, Tianjin University, Tianjin 300354

Received:2017-02-13 Revised:2017-08-05 Online:2018-01-05 Published:2018-01-05

摘要/Abstract

摘要： 针对颅骨组织工程支架由于缺乏血管结构从而限制了细胞的生长及成骨量的形成等问题，提出一种基于人体颅骨板障静脉特征的血管支架参数化设计方法。通过显微计算机断层扫描技术（Micro computed tomography，显微CT），对天然颅骨样本进行扫描、脉管特征识别和形态分析，基于二叉树结构，建立血管支架的参数化模型，并基于人体静脉血流特征，建立流固单向耦合有限元模型，分析流动血液对弹性血管结构的影响。结果表明该血管支架可实现参数化的结构设计，并具有血液流动功能，主血管以及带小血管的血管段血流稳定，流体压力、速度和剪切力的分布满足层流规律，血管的变形和应力分布基本合理。该方法可用于指导与完善血管设计，为颅骨组织工程支架体外血管化奠定基础。

关键词: 参数化, 二叉树, 流固耦合, 颅骨组织工程, 血管支架

Abstract: Due to lack of the vascular structure in skull tissue engineering scaffold, the amount of cell growth and bone formation are limited. Based on the characteristics of human skull diploe vein, a vascular scaffold parametric design method is presented. Aimed to a nature skull sample, through the technology of micro CT scanning, vascular feature identification and morphological analysis are applied, and a parametric model of vascular scaffold is built using binary tree structure. According to the venous blood flow characters of human body, one way fluid-structure coupling finite element model is established to analyze the effect of flow blood on elastic vascular structure. The results show that the parametric design for the vascular scaffold can be realized and its blood flow function is achieved. The flow of the main blood vessels and the small blood vessels segments is stable. The distributions of fluid pressure, velocity and shear force meet the law of laminar flow, and the deformation and stress are reasonable. This method can be used to guide and improve the vascular structure design, which lays a foundation for skull tissue engineering scaffold vascularization in vitro.

Key words: binary tree, fluid-structure coupling, parameterization, skull tissue engineering, vascular scaffold

中图分类号:

TP391

刘洁, 郑淑贤, 李佳. 颅骨组织工程血管支架的参数化设计[J]. 机械工程学报, 2018, 54(1): 178-187.

LIU Jie, ZHENG Shuxian, LI Jia. Parametric Design for Skull Tissue Engineering Vascular Scaffold[J]. Journal of Mechanical Engineering, 2018, 54(1): 178-187.

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颅骨组织工程血管支架的参数化设计

Parametric Design for Skull Tissue Engineering Vascular Scaffold

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