Abstract: For enhancing the pore curvature of tissue engineering scaffold made by rapid prototyping (RP), low-temperature deposition manufacturing (LDM) and electrospinning are composited to manufacture multi-scale one. For simulating the forming process, the algorithm of level set method (LSM) is applied in the research of the tracking of free boundary for liquid-solid phase transition process. Based on both heat-transfer theory and incompressible liquid Navier-Stokes (N-S) equation, the mathematical model of materials solidification and deformation for LDM is built. The concept of flow disturbance is introduced for describing that solidification has an effect on flow deformation. The problem of multiphasics coupling is simulated. Moreover, the constitutive equation of electrostatic field is used to simulate the field strength for “tip to board” construct. The experiments of LDM and electrospinning are recorded by high speed CCD. The calculation results are in good agreement with the experimental results, and offer the theoretical direction of environment temperature, forming speed, the diameter of accepting board, the distance of electrospinning, etc. Experimental results show that these theory methods are effective and reliable.

Key words: Electrospinning, Level set method, Low-temperature deposition manufacturing, Multi-physics coupling, Tissue engineering scaffold