Fabrication of Polyetherimide Macro/micro Porous Structure Using a Combination of 3D Printing and Non-solvent Induced Phase Separation

doi:10.3901/JME.2022.15.283

Abstract

Abstract: There has been increasing attention to polyetherimide(PEI) recently, which is a medical implant material with excellent physical properties and biocompatibility.The printing slurry is prepared using polyetherimide(PEI) powder and N-methyl pyrrolidone(NMP) solvent.The PEI product with macro porous structure is 3 D printed under controllable environmental humidity and the micro pore structure of the PEI product is formed after non-solvent induced phase separation and heat drying.Thus, the PEI product with macro/micro composite porous structure is obtained.It is verified that NMP is completely removed from the PEI product through the analysis of the thermogravimetric(TG) curve and Fourier transform infrared(FT-IR) spectroscopy;The macro and micro morphology of PEI product are analysed by electron microscope and scanning electron microscope.The results show that the macropore sizes are 470-550 μm, the micropore sizes are less than 20 μm, and the porosity is 57% -61%;The mechanical tests show that the maximum tensile strength of PEI product is 11.72 MPa and the maximum elastic modulus is 383 MPa.The PEI products with macro/micro porous structure can be fabricated using the process combining 3 D printing and non-solvent induced phase separation, which has potential application prospects in medical implant scaffolds.

Key words: non-solvent induced phase separation, 3D printing, macro/micro porous structure, polyetherimide(PEI)

CLC Number:

TH164

ZHANG Liyan, GAO Lijie, MA Haopeng, JIAO Zhiwei, YANG Weimin, YU Yuan. Fabrication of Polyetherimide Macro/micro Porous Structure Using a Combination of 3D Printing and Non-solvent Induced Phase Separation[J]. Journal of Mechanical Engineering, 2022, 58(15): 283-291.

References

[1] 闫普选, 王晓东, 朱鹏, 等.热塑性聚酰亚胺多孔材料制备及表征[J].轴承, 2006(8):19-22.YAN Puxuan, WANG Xiaodong, ZHU Peng, et al.Preparation and characterization of porous thermoplastic polyamide[J]. Bearing, 2006(8):19-22.
[2] YUAN K, PENG C, XUE T S, et al. Preparation of open-porous stereocomplex PLA/PBAT scaffolds and correlation between their morphology, mechanical behavior, and cell compatibility[J]. RSC Advances, 2018, 8(23):12933-12943
[3] LOH Q L, CHOONG C. Three-dimensional scaffolds for tissue engineering applications:Role of porosity and pore size[J]. Tissue Engineering Part B Reviews, 2013, 19(6):485-502.
[4] REZABEIGI E, WOOD-ADAMS P M, DREW R A L.Production of porous polylacticacid monoliths via nonsolvent induced phase separation[J]. Polymer, 2014, 55(26):6743-6753.
[5] KAROLA L, WEIGEL T, LENDLEIN A. Polyetherimide scaffolds as multifunctional materials for potential applications in regenerative medicine[J]. Artificial Organs, 2010, 30(10):764-769.
[6] SEIFERT B, MIHANETZIS G, GROTH T, et al.Polyetherimide:A new membrane-forming polymer for biomedical applications[J]. Artificial Organs, 2002, 26(2):189-199.
[7] MEROLLI A, PERRONE V, LEALI P T, et al. Response to polyetherimide based composite materials implanted in muscle and in bone[J]. Journal of Materials Science Materials in Medicine, 1999, 10(5):265-268.
[8] ZHANG Y, LI R, WU W, et al. Adhesion and proliferation of osteoblast-like cells on porous polyetherimide scaffolds[J]. BioMed Research International, 2018, 2018:1-7.
[9] KOSTOPOULOS V, KOTROTSOS A, FOURILI K, et al. Fabrication and characterization of polyetherimide electrospun scaffolds modified with graphene nano-platelets and hydroxyapatite nano-particles[J].International Journal of Molecular Sciences, 2020, 21(2):1-16.
[10] FENG D, LIU P, WANG Q. Exploiting the piezoresistivity and EMI shielding of polyetherimide/carbon nanotube foams by tailoring their porous morphology and segregated CNT networks[J].Composites:Part A, Applied Science&, 2019, 124:105463.
[11] LI D, ZHANG H, LI X. Porous polyetherimide membranes with tunable morphology for lithium-ion battery[J]. Journal of Membrane Science, 2018, 565:42-49.
[12] 王旭霞.相转化法制备聚醚酰亚胺锂离子电池隔膜及其性能研究[D].北京:北京理工大学, 2016.WANG Xuxia. Preparation and Characterization of Polyetherimide separators for lithium ion battery by phase transition[D]. Beijing:Beijing Institute of Technology, 2016.
[13] 王清瑞, 田小永, 汪鑫.聚醚酰亚胺的熔融沉积成型[C]//第17届全国特种加工学术会议. 2017.WANG Qingrui, TIAN Xiaoyong, WANG Xin. Melt deposition molding of polyetherimide[C]//The 17th National Academic Conference on Special Processing.2017.
[14] 刘顶, 李露瑶, 肖洁, 等. 3D打印PEI成型工艺对制品力学性能的影响[J].塑料, 2018, 47(6):94-97.LIU Ding, LI Luyao, XIAO Jie, et al. Effect of 3D printing PEI molding process on mechanical properties of products[J]. Plastics, 2018, 47(6):94-97.
[15] TANG X, QIN Y, XU X, et al. Fabrication and in vitro evaluation of 3D printed porous polyetherimide scaffolds for bone tissue engineering[J]. Biomed Research International, 2019, 2019(5):1-8.
[16] 马昊鹏, 高丽洁, 焦志伟, 等.非溶剂致相分离3D打印/复印成型技术研究[J].中国塑料, 2020, 34(12):1-7.MA Haopeng, GAO Lijie, JIAO Zhiwei, et al.Non-solvent induced phase separation 3D printing/copying technology research[J]. China Plastics, 2020, 34(12):1-7.
[17] 杨卫民, 马昊鹏, 焦志伟, 等.一种基于固相析出分离工艺的聚合物3D打印成型方法:CN110142957A[P].2019-08-20.YANG Weimin, MA Haopeng, JIAO Zhiwei, et al. A polymer 3D printing molding method based on solid phase precipitation and separation technology:CN110142957A[P]. 2019-08-20.
[18] 高丽洁.非溶剂致相分离3D打印聚合物的成型工艺及应用研究[D].北京:北京化工大学, 2021.GAO Lijie. Research on the forming process and application of non-solvent induced phase separation 3D printing polymer[D]. Beijing:Beijing University of Chemical Technology, 2021.
[19] SOHN D G, HONG M W, KIM Y Y, et al. Fabrication of dual-pore scaffolds using a combination of wire-networked molding(WNM) and non-solvent induced phase separation(NIPS) techniques[J]. Journal of Bionic Engineering, 2015, 12(004):565-574.
[20] KOENHEN D M, MULDER M, SMOLDERS C. Phase separation phenomena during the formation of asymmetric membranes[J]. Journal of Applied Polymer Science, 2010, 21(1):199-215.
[21] GUILLEN G R, PAN Y, LI M, et al. Preparation and characterization of membranes formed by nonsolvent induced phase separation:A review[J]. Industrial&Engineering Chemistry Research, 2011, 50(7):3798-3817.
[22] JIAO Z, LUO B, XIANG S, et al. 3D printing of HA/PCL composite tissue engineering scaffolds[J]. Advanced Industrial and Engineering Polymer Research, 2019, 2(4):196-202
[23] BAKERI G, ISMAIL A F, RAHIMNEIAD M, et al.Analysis of Polyetherimide/N-Methyl-2-Pyrrolidone/nonsolvent phase separation behavior[J]. Journal of Polymer Research, 2014, 21(4):386.
[24] 丑树人, 任吉中, 李晖, 等.高性能聚醚酰亚胺中空纤维气体分离膜的制备与分离性能[J].膜科学与技术, 2010, 30(3):21-26.CHOU Shuren, REN Jizhong, LI Hui, et al. Preparation and separation performance of high performance polyetherimide hollow fiber gas separation membrane[J].Membrane Science and Technology, 2010, 30(3):21-26.
[25] VAN S, CHAI Y C, TRUSCELLO S, et al. The effect of pore geometry on the in vitro biological behavior of human periosteum-derived cells seeded on selective laser-melted Ti6Al4V bone scaffolds[J]. Acta Biomaterialia, 2012, 8(7):2824-2834.
[26] KARAGEORGIOU V, KAPLAN D. Porosity of 3D biomaterial scaffolds and osteogenesis[J]. Biomaterials, 2005, 26(27):5474-5491.
[27] 张航, 许宋锋, 熊胤泽, 等.多孔β-TCP生物陶瓷DLP打印工艺研究[J].机械工程学报, 2019, 55(15):81-87.ZHANG Hang, XU Songfeng, XIONG Yinze, et al.Fabrication of porous β-TCP bioceramics using digital light processing[J]. Journal of Mechanical Engineering, 2019, 55(15):81-87.
[28] KASHIRINA A, YAO Y, LIU Y, et al. Biopolymers as bone substitutes:A review[J]. Biomaterials Science, 2019, 7(10):3961-3983.