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  首页《机械工程学报》2008年7期目录→钛系生物医用材料表面粗糙度影响细胞黏附的新进展

钛系生物医用材料表面粗糙度影响细胞黏附的新进展

 

梁迎春  宋代平  陈明君  白清顺

(哈尔滨工业大学精密工程研究所 哈尔滨 150001)

 

摘要:详细介绍粗糙表面细胞的黏附机理,结合表面加工方法较全面地总结和分析钛系材料不同表面粗糙度对细胞黏附的影响及细胞黏附的表面粗糙度模型。综述表明:粗糙表面通过改变表面力场、表面电荷和表面能、增加比表面积及表面缺陷等方式促进细胞在植入体表面的黏附;钛系材料表面粗糙度对不同细胞黏附的影响不同,粗糙表面可促进细胞基因表达;由于表面加工方法造成表面化学状态变化并影响表面电荷和表面能,所以应根据不同的表面加工方法来设计植入体的表面形貌,以获得适合细胞黏附的表面粗糙度。此外,探讨钛表面细胞吸附的分子动力学研究方法,结果显示可利用分子动力学方法在分子水平研究表面特征对蛋白质和细胞黏附的影响机理。

关键词:钛系生物医用材料  表面粗糙度  细胞黏附  生物分子动力学仿真

中图分类号:TG146.2

国家自然科学基金(50675050)和哈尔滨工业大学校交叉基金(HIT. MD2003.10)资助项目。20070830收到初稿,20080218收到修改稿

 
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作者简介:梁迎春,男,1964年出生,教授,博士生导师。主要研究方向为超精密加工及纳米技术、现代机械设计理论与方法、生物制造工程,已发表论文70余篇。
E-mail:ycliang@hit.edu.cn

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