From Robot to Micro/nanorobot: Changes Not Only Dimensions

doi:10.3901/JME.2024.23.001

Abstract

Abstract: With the wide application of robotics in industrial, healthcare, service, education and military fields, the traditional macro-robotics technology is gradually unable to meet the growing demand for miniaturization, refinement and highly integrated functions. As an emerging branch in the field of robotics, micro/nanorobots (MNRs) have become a hotspot and frontier of research because of their micro size, large thrust-to-weight ratio, good controllability and strong expandability. By reviewing the development history of robotics, the four stages of robot development and five generations of power conversion are analyzed in detail, and the technical characteristics that robots should have are summarized. On this basis, the development history, connotation and technological stage of MNRs are discussed in-depth, focusing on the analysis of the fundamental changes from macro robots to MNRs in terms of medium environment, drive mode, transport mode and multifunctional coupling mode and other technical characteristics, as well as the technological challenges brought about by these changes. In particular, the advanced changes of MNRs are discussed in detail from four aspects, namely, design, manufacturing, control and testing. Finally, future directions and suggestions for the development of MNRs are presented. By exploring these issues in detail, theoretical guidance and practical basis are provided for the development of future robotics technology. It is expected that MNRs technology can achieve breakthroughs in more fields, provide new technical solutions for precision medicine, environmental governance, micro-and nanomanufacturing, etc., and promote the continuous progress of society and science and technology.

Key words: micro/nanorobot, robot, testing, control, design, manufacturing

CLC Number:

TP242

LI Longqiu, LIU Junmin, ZHUANG Rencheng, CHANG Xiaocong, ZHOU Dekai. From Robot to Micro/nanorobot: Changes Not Only Dimensions[J]. Journal of Mechanical Engineering, 2024, 60(23): 1-20.

References

[1] JAVAID M，HALEEM A，SINGH R P，et al. Substantial capabilities of robotics in enhancing industry 4.0 implementation[J]. Cognitive Robotics，2021，1：58-75.
[2] KONG M，WU P，ZHANG Y，et al. Energy-efficient scheduling model and method for assembly blocking permutation flow-shop in industrial robotics field[J]. Artificial Intelligence Review，2024，57(3)：60.
[3] KYRARINI M，LYGERAKIS F，RAJAVENKATANAR AYANAN A，et al. A survey of robots in healthcare[J]. Technologies，2021，9(1)：8.
[4] LIU X，HUANG C，ZHU H，et al. State-of-the-art elderly service robot：Environmental perception，compliance control，intention recognition，and research challenges[J]. IEEE Systems，Man，and Cybernetics Magazine，2024，10(1)：2-16.
[5] SHAHAB M，TAHERI A，MOKHTARI M，et al. Utilizing social virtual reality robot (V2R) for music education to children with high-functioning autism[J]. Education and Information Technologies，2022，27：819-843.
[6] GANS N R，ROGERS J G. Cooperative multirobot systems for military applications[J]. Current Robotics Reports，2021，2：105-111.
[7] LIU L，GUO F，ZOU Z，et al. Application，development and future opportunities of collaborative robots (cobots) in manufacturing：A literature review[J]. International Journal of Human–Computer Interaction，2024，40(4)：915-932.
[8] SU H，LI S，YANG G Z，et al. Janus micro/nanorobots in biomedical applications[J]. Advanced Healthcare Materials，2023，12(16)：2202391.
[9] YANG Y，JIAO P. Nanomaterials and nanotechnology for biomedical soft robots[J]. Materials Today Advances，2023，17：100338.
[10] HUANG X，QI Y，BU T，et al. Overview of advanced micro-nano manufacturing technologies for triboelectric nanogenerators[J]. Nanoenergy Advances，2022，2(4)：316-343.
[11] WANG Y，ZHANG X，XU J，et al. The development of microscopic imaging technology and its application in micro-and nanotechnology[J]. Frontiers in Chemistry，2022，10：931169.
[12] ZHENG J，QI R，DAI C，et al. Enzyme catalysis biomotor engineering of neutrophils for nanodrug delivery and cell-based thrombolytic therapy[J]. ACS Nano，2022，16(2)：2330-2344.
[13] PARK J，KIM J Y，PANé S，et al. Acoustically mediated controlled drug release and targeted therapy with degradable 3D porous magnetic microrobots[J]. Advanced Healthcare Materials，2021，10(2)：2001096.
[14] KIM S，QIU F，KIM S，et al. Fabrication and characterization of magnetic microrobots for three-dimensional cell culture and targeted transportation[J]. Advanced Materials，2013，25(41)：5863-5868.
[15] JEON S，KIM S，HA S，et al. Magnetically actuated microrobots as a platform for stem cell transplantation[J]. Science Robotics，2019，4(30)：eaav4317.
[16] JEON S，HOSHIAR A K，KIM K，et al. A magnetically controlled soft microrobot steering a guidewire in a three- dimensional phantom vascular network[J]. Soft Robotics，2019，6(1)：54-68.
[17] HUSSEIN H，DAMDAM A，REN L，et al. Actuation of mobile microbots：A review[J]. Advanced Intelligent Systems，2023，5(9)：2300168.
[18] YANG J，ZHENG J，AI R，et al. Plasmon-enhanced，self-traced nanomotors on the surface of silicon[J]. Angewandte Chemie，2021，133(47)：25162-25171.
[19] LI J，GAO W，DONG R，et al. Nanomotor lithography[J]. Nature Communications，2014，5(1)：5026.
[20] DAI J，CHENG X，LI X，et al. Solution-synthesized multifunctional Janus nanotree microswimmer[J]. Advanced Functional Materials，2021，31(48)：2106204.
[21] CHEN L，GAN Q，XIAO X，et al. Bio-templated synthesis of MnO₂-based micromotors for enhanced heavy metal removal from aqueous solutions[J]. Journal of Materials Science，2024，59(10)：4267-4280.
[22] ROSSI C，RUSSO F. Automata (towards automation and robots)[M]. Springer International Publishing，2017.
[23] MORAN M E. Evolution of robotic arms[J]. Journal of Robotic Surgery，2007，1(2)：103-111.
[24] FRESCHI C，FERRARI V，MELFI F，et al. Technical review of the da vinci surgical telemanipulator[J]. The International Journal of Medical Robotics and Computer Assisted Surgery，2013，9(4)：396-406.
[25] KUINDERSMA S，DEITS R，FALLON M，et al. Optimization-based locomotion planning，estimation，and control design for the atlas humanoid robot[J]. Autonomous Robots，2016，40：429-455.
[26] SOLIMAN W S. Guardian of time flow：Baboon on the water clock during the greco-roman period[J]. Journal of Association of Arab Universities for Tourism and Hospitality，1999，23(2)：185-219.
[27] YAN H S，LIN T Y. A study on ancient chinese time laws and the time-telling system of su song’s clock tower[J]. Mechanism and Machine Theory，2002，37(1)：15-33.
[28] XIDONG J. The productivity level of the song dynasty[J]. Social Sciences in China，2023，44(2)：74-93.
[29] MORAN M E. Jacques de vaucanson：The father of simulation[J]. Journal of Endourology，2007，21(7)：679- 683.
[30] IAVAZZO C，GKEGKE X E D，IAVAZZO P E，et al. Razvoj robota kroz povijest do “da vincijevog robota”[J]. Acta Medico-Historica Adriatica，2014，12(2)：247-258.
[31] PORTER C I. Taking the Jacquard industry into the 1990s[J]. Textile Progress，1989，19(4)：8-18.
[32] EVANS T. The race of machines：Blackness and prosthetics in early american science fiction[J]. American Literature，2018，90(3)：553-584.
[33] VUKOBRATOVIĆ M. Nikola tesla and robotics[J]. Serbian Journal of Electrical Engineering，2006，3(2)：163-175.
[34] ENGELBERGER J F. Designing robots for industrial environments[J]. Mechanism and Machine Theory，1977，12(5)：403-412.
[35] QIANG T，WOLFF M. English in china today at the harbin institute of technology：Volume i[M]. Cambridge Scholars Publishing，2012.
[36] KUIPERS B，FEIGENBAUM E A，HART P E，et al. Shakey：From conception to history[J]. Ai Magazine，2017，38(1)：88-103.
[37] BORBONI A，REDDY K V V，ELAMVAZUTHI I，et al. The expanding role of artificial intelligence in collaborative robots for industrial applications：A systematic review of recent works[J]. Machines，2023，11(1)：111.
[38] GU H，MöCKLI M，EHMKE C，et al. Self-folding soft-robotic chains with reconfigurable shapes and functionalities[J]. Nature Communications，2023，14(1)：1263.
[39] SHAO G，WARE H O T，HUANG J，et al. 3D printed magnetically-actuating micro-gripper operates in air and water[J]. Additive Manufacturing，2021，38：101834.
[40] HAO B，WANG X，DONG Y，et al. Focused ultrasound enables selective actuation and newton-level force output of untethered soft robots[J]. Nature Communications，2024，15(1)：5197.
[41] STANDARDIZATION I O F. ISO 8373：2021 Robotics–Vocabulary[Z]. ISO/TC 299. 2021.
[42] LUO Z，CHENG W，ZHAO T，et al. Intelligent sensory systems toward soft robotics[J]. Applied Materials Today，2024，37：102122.
[43] 牛丽周，丁亮，高海波，等. 软体足式机器人驱动、建模与仿真研究综述[J]. 机械工程学报，2021，57(19)：1-20. NIU Lizhou，DING Liang，GAO Haibo，et al. Review of actuation，modeling and simulation in soft-legged robot[J]. Chinese Journal of Mechanical Engineering，2021，57(19)：1-20.
[44] ZACHARAKI A，KOSTAVELIS I，GASTERATOS A，et al. Safety bounds in human robot interaction：A survey[J]. Safety Science，2020，127：104667.
[45] 赖一楠，叶鑫，丁汉. 共融机器人重大研究计划研究进展[J]. 机械工程学报，2021，57(23)：1-11，20. LAI Yinan，YE Xin，DING Han. Research progress of major research plan on tri-co robots[J]. Chinese Journal of Mechanical Engineering，2021，57(23)：1-11，20.
[46] REN K，YU J. Research status of bionic amphibious robots：A review[J]. Ocean Engineering，2021，227：108862.
[47] SUN H，WEI C，YAO Y A，et al. Analysis and experiment of a bioinspired multimode octopod robot[J]. Chinese Journal of Mechanical Engineering，2023，36(1)：142.
[48] YE J，FAN Y，NIU G，et al. Intelligent micro/ nanomotors：Fabrication，propulsion，and biomedical applications[J]. Nano Today，2024，55：102212.
[49] JING X，GUO W. Modeling and configuration design of electromagnetic actuation coil for a magnetically controlled microrobot[J]. Chinese Journal of Mechanical Engineering，2019，32(1)：63.
[50] FEYNMAN R. There’s plenty of room at the bottom[J]. Resonance，2011，16：890-905.
[51] PAXTON W F，KISTLER K C，OLMEDA C C，et al. Catalytic nanomotors：Autonomous movement of striped nanorods[J]. Journal of the American Chemical Society，2004，126(41)：13424-13431.
[52] LIU W，CHEN X，LU X，et al. From passive inorganic oxides to active matters of micro/nanomotors[J]. Advanced Functional Materials，2020，30(39)：2003195.
[53] CHEN C，DING S，WANG J. Materials consideration for the design，fabrication and operation of microscale robots[J]. Nature Reviews Materials，2024，9：159-172.
[54] HERMANOVá S，PUMERA M. Polymer platforms for micro-and nanomotor fabrication[J]. Nanoscale，2018，10(16)：7332-7342.
[55] BANNO T，UENO K，KOJIMA T，et al. Induction for self-propelled motion of artificial objects with/without shape anisotropy[J]. Journal of Oleo Science，2024，73(4)：509-518.
[56] KATURI J，MA X，STANTON M M，et al. Designing micro-and nanoswimmers for specific applications[J]. Accounts of Chemical Research，2017，50(1)：2-11.
[57] SáNCHEZ S，SOLER L，KATURI J. Chemically powered micro-and nanomotors[J]. Angewandte Chemie International Edition，2015，54(5)：1414-1444.
[58] ELNAGGAR A，KANG S，TIAN M，et al. State of the art in actuation of micro/nanorobots for biomedical applications[J]. Small Science，2024，4(3)：2300211.
[59] PREETAM S，PRITAM P，MISHRA R，et al. Empowering tomorrow’s medicine：Energy-driven micro/ nano-robots redefining biomedical applications[J]. Molecular Systems Design & Engineering，2024，9：892-911.
[60] CHEN Y，CHEN D，LIANG S，et al. Recent advances in field-controlled micro–nano manipulations and micro- nano robots[J]. Advanced Intelligent Systems，2022，4(3)：2100116.
[61] MUñOZ J，URSO M，PUMERA M. Self-propelled multifunctional microrobots harboring chiral supramolecular selectors for “enantiorecognition-on-the-fly”[J]. Angewandte Chemie International Edition，2022，61(14)：e202116090.
[62] GAO W，PEI A，DONG R，et al. Catalytic iridium-based Janus micromotors powered by ultralow levels of chemical fuels[J]. Journal of the American Chemical Society，2014，136(6)：2276-2279.
[63] WANG J，TOEBES B J，PLACHOKOVA A S，et al. Self- propelled PLGA micromotor with chemotactic response to inflammation[J]. Advanced Healthcare Materials，2020，9(7)：1901710.
[64] VILELA D，COSSíO U，PARMAR J，et al. Medical imaging for the tracking of micromotors[J]. ACS Nano，2018，12(2)：1220-1227.
[65] ZHANG Y，ZHANG L，YANG L，et al. Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of C. diff toxins[J]. Science Advances，2019，5(1)：eaau9650.
[66] PATIñO T，FEINER-GRACIA N，ARQUÉ X，et al. Influence of enzyme quantity and distribution on the self- propulsion of non-Janus urease-powered micromotors[J]. Journal of the American Chemical Society，2018，140(25)：7896-7903.
[67] CAO W，LIU Y，RAN P，et al. Ultrasound-propelled janus rod-shaped micromotors for site-specific sonodynamic thrombolysis[J]. ACS Applied Materials & Interfaces，2021，13(49)：58411-58421.
[68] SOLOVEV A A，MEI Y，BERMúDEZ UREñA E，et al. Catalytic microtubular jet engines self-propelled by accumulated gas bubbles[J]. Small，2009，5(14)：1688- 1692.
[69] YU Y，SHANG L，GAO W，et al. Microfluidic lithography of bioinspired helical micromotors[J]. Angewandte Chemie，2017，129(40)：12295-12299.
[70] LIU Y，GE D，CONG J，et al. Magnetically powered annelid-worm-like microswimmers[J]. Small，2018，14(17)：1704546.
[71] HUANG T-Y，SAKAR M S，MAO A，et al. 3D printed microtransporters：Compound micromachines for spatiotemporally controlled delivery of therapeutic agents[J]. Advanced Materials，2015，27(42)：6644-6650.
[72] CUI D，YAN Z，CHEN X，et al. Electroosmotic flow spin tracers near chemical nano/micromotors[J]. Nanoscale，2024，16(6)：2847-2851.
[73] ZHAO Z，CHEN J，ZHAN G，et al. Controlling the collective behaviors of ultrasound-driven nanomotors via frequency regulation[J]. Micromachines，2024，15(2)：262.
[74] XIONG J，LI X，HE Z，et al. Light-controlled soft bio-microrobot[J]. Light：Science & Applications，2024，13(1)：55.
[75] ZHUANG R，ZHOU D，CHANG X，et al. Alternating current electric field driven topologically defective micro/nanomotors[J]. Applied Materials Today，2022，26：101314.
[76] ZHOU D，YUE H，CHANG X，et al. Mimicking motor proteins：Wall-guided self-navigation of microwheels[J]. ACS Nano，2024，18(12)：8853-8862.
[77] WU J，JIAO N，LIN D，et al. Dual-responsive nanorobot-based marsupial robotic system for intracranial cross-scale targeting drug delivery[J]. Advanced Materials，2024，36(9)：2306876.
[78] ASTUMIAN R D. How molecular motors work–insights from the molecular machinist’s toolbox：The nobel prize in chemistry 2016[J]. Chemical Science，2017，8(2)：840-845.
[79] MISKIN M Z，CORTESE A J，DORSEY K，et al. Electronically integrated，mass-manufactured，microscopic robots[J]. Nature，2020，584(7822)：557-561.
[80] LI T，CHANG X，WU Z，et al. Autonomous collision-free navigation of microvehicles in complex and dynamically changing environments[J]. ACS Nano，2017，11(9)：9268-9275.
[81] ZHANG H，LI Z，GAO C，et al. Dual-responsive biohybrid neutrobots for active target delivery[J]. Science Robotics，2021，6(52)：eaaz9519.
[82] YANG M，ZHANG Y，MOU F，et al. Swarming magnetic nanorobots bio-interfaced by heparinoid-polymer brushes for in vivo safe synergistic thrombolysis[J]. Science Advances，2023，9(48)：eadk7251.
[83] YUE H，CHANG X，LIU J，et al. Wheel-like magnetic- driven microswarm with a band-aid imitation for patching up microscale intestinal perforation[J]. ACS Applied Materials & Interfaces，2022，14(7)：8743-8752.
[84] PENG X，URSO M，KOLACKOVA M，et al. Biohybrid magnetically driven microrobots for sustainable removal of micro/nanoplastics from the aquatic environment[J]. Advanced Functional Materials，2024，34(3)：2307477.
[85] LI T，LI J，ZHANG H，et al. Magnetically propelled fish- like nanoswimmers[J]. Small，2016，12(44)：6098-6105.
[86] XU H，MEDINA-SáNCHEZ M，MAGDANZ V，et al. Sperm-hybrid micromotor for targeted drug delivery[J]. ACS Nano，2018，12(1)：327-337.
[87] ZENG M，YUAN S，HUANG D，et al. Accelerated design of catalytic water-cleaning nanomotors via machine learning[J]. ACS Applied Materials & Interfaces，2019，11(43)：40099-40106.
[88] XU H，WU S，LIU Y，et al. 3D nanofabricated soft microrobots with super-compliant picoforce springs as onboard sensors and actuators[J]. Nature Nanotechnology，2024，19：494-503.
[89] LIN Z，FAN X，SUN M，et al. Magnetically actuated peanut colloid motors for cell manipulation and patterning[J]. ACS Nano，2018，12(3)：2539-2545.
[90] YANG Q，XU H，WEN H，et al. Graphene oxide induced enhancement of light-driven micromotor with biocompatible fuels[J]. Applied Materials Today，2021，22：100943.
[91] GORDóN J，ARRUZA L，IBáñEZ M D，et al. On the move-sensitive fluorescent aptassay on board catalytic micromotors for the determination of interleukin-6 in ultra-low serum volumes for neonatal sepsis diagnostics[J]. ACS Sensors，2022，7(10)：3144-3152.
[92] REN L，ZHOU D，MAO Z，et al. Rheotaxis of bimetallic micromotors driven by chemical-acoustic hybrid power[J]. ACS Nano，2017，11(10)：10591-10598.
[93] MARIC T，NASIR M Z M，WEBSTER R D，et al. Tailoring metal/TiO₂ interface to influence motion of light-activated Janus micromotors[J]. Advanced Functional Materials，2020，30(9)：1908614.
[94] VALDEZ-GARDUñO M，LEAL-ESTRADA M，OLIVEROS-MATA E S，et al. Density asymmetry driven propulsion of ultrasound-powered Janus micromotors[J]. Advanced Functional Materials，2020，30(50)：2004043.
[95] CHANG X，LI L，LI T，et al. Accelerated microrockets with a biomimetic hydrophobic surface[J]. RSC Advances，2016，6(90)：87213-87220.
[96] LU X，OU H，WEI Y，et al. Superfast fuel-free tubular hydrophobic micromotors powered by ultrasound[J]. Sensors and Actuators B：Chemical，2022，372：132667.
[97] ZHOU M，XING Y，LI X，et al. Cancer cell membrane camouflaged semi-yolk@ spiky-shell nanomotor for enhanced cell adhesion and synergistic therapy[J]. Small，2020，16(39)：2003834.
[98] POURRAHIMI A M，VILLA K，YING Y，et al. ZnO/ZnO₂/Pt Janus micromotors propulsion mode changes with size and interface structure：Enhanced nitroaromatic explosives degradation under visible light[J]. ACS Applied Materials & Interfaces，2018，10(49)：42688-42697.
[99] POURRAHIMI A M，VILLA K，MANZANARES PALENZUELA C L，et al. Catalytic and light-driven ZnO/Pt Janus nano/micromotors：Switching of motion mechanism via interface roughness and defect tailoring at the nanoscale[J]. Advanced Functional Materials，2019，29(22)：1808678.
[100] ZHENG C，LI Z，XU T，et al. Spirulina-templated porous hollow carbon@ magnetite core-shell microswimmers[J]. Applied Materials Today，2021，22：100962.
[101] CEYLAN H，YASA I C，YASA O，et al. 3D-printed biodegradable microswimmer for theranostic cargo delivery and release[J]. ACS Nano，2019，13(3)：3353-3362.
[102] REN M，GUO W，GUO H，et al. Microfluidic fabrication of bubble-propelled micromotors for wastewater treatment[J]. ACS Applied Materials & Interfaces，2019，11(25)：22761-22767.
[103] LI J，SATTAYASAMITSATHIT S，DONG R，et al. Template electrosynthesis of tailored-made helical nanoswimmers[J]. Nanoscale，2014，6(16)：9415-9420.
[104] WANG W，WU Z，LIN X，et al. Gold-nanoshell- functionalized polymer nanoswimmer for photomechanical poration of single-cell membrane[J]. Journal of the American Chemical Society，2019，141(16)：6601-6608.
[105] ZHOU J，KARSHALEV E，MUNDACA-URIBE R，et al. Physical disruption of solid tumors by immunostimulatory microrobots enhances antitumor immunity[J]. Advanced Materials，2021，33(49)：2103505.
[106] KWAK M，JUNG I，KANG Y G，et al. Multi-block magnetic nanorods for controlled drug release modulated by fourier transform surface plasmon resonance[J]. Nanoscale，2018，10(39)：18690-18695.
[107] GUO J，GALLEGOS J J，TOM A R，et al. Electric-field-guided precision manipulation of catalytic nanomotors for cargo delivery and powering nanoelectromechanical devices[J]. ACS Nano，2018，12(2)：1179-1187.
[108] ZHU J，WANG H，ZHANG Z. Shape-tunable Janus micromotors via surfactant-induced dewetting[J]. Langmuir，2021，37(16)：4964-4970.
[109] XU B，ZHANG X，TIAN Z，et al. Microdroplet-guided intercalation and deterministic delamination towards intelligent rolling origami[J]. Nature Communications，2019，10(1)：5019.
[110] DONG Y，WANG L，YUAN K，et al. Magnetic microswarm composed of porous nanocatalysts for targeted elimination of biofilm occlusion[J]. ACS Nano，2021，15(3)：5056-5067.
[111] WANG X，SRIDHAR V，GUO S，et al. Fuel-free nanocap-like motors actuated under visible light[J]. Advanced Functional Materials，2018，28(25)：1705862.
[112] XIE H，SUN M，FAN X，et al. Reconfigurable magnetic microrobot swarm：Multimode transformation，locomotion，and manipulation[J]. Science Robotics，2019，4(28)：eaav8006.
[113] ZHOU D，GAO Y，YANG J，et al. Light-ultrasound driven collective “firework” behavior of nanomotors[J]. Advanced Science，2018，5(7)：1800122.
[114] FENG Y，JIA D，YUE H，et al. Breaking through barriers：Ultrafast microbullet based on cavitation bubble[J]. Small，2023，19(18)：2207565.
[115] WANG S，GUO X，XIU W，et al. Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles[J]. Science Advances，2020，6(31)：eaaz8204.
[116] LIANG X，MOU F，HUANG Z，et al. Hierarchical microswarms with leader–follower-like structures：Electrohydrodynamic self-organization and multimode collective photoresponses[J]. Advanced Functional Materials，2020，30(16)：1908602.
[117] ZHANG S，MOU F，YU Z，et al. Heterogeneous sensor-carrier microswarms for collaborative precise drug delivery toward unknown targets with localized acidosis[J]. Nano Letters，2024，24(20)：5958-5967
[118] CAO C，MOU F，YANG M，et al. Harnessing disparities in magnetic microswarms：From construction to collaborative tasks[J]. Advanced Science，2024，11(30)：2401711.
[119] SU Y Y，ZHANG M J，WANG W，et al. Bubble-propelled hierarchical porous micromotors from evolved double emulsions[J]. Industrial & Engineering Chemistry Research，2019，58(4)：1590-1600.
[120] GHOSH A，LI L，XU L，et al. Gastrointestinal-resident，shape-changing microdevices extend drug release in vivo[J]. Science Advances，2020，6(44)：eabb4133.
[121] LIU J，HUANG Z，YUE H，et al. A magnetic field- driven multi-functional “medical ship” for intestinal tissue collection in vivo[J]. Nanoscale，2023，15(38)：15831-15839.
[122] ESTEBAN-FERNáNDEZ DE ÁVILA B，ANGSANTIKUL P，RAMíREZ-HERRERA D E，et al. Hybrid biomembrane-functionalized nanorobots for concurrent removal of pathogenic bacteria and toxins[J]. Science Robotics，2018，3(18)：eaat0485.
[123] FAN Z，GAO R X，HE Q，et al. New sensing technologies for monitoring machinery，structures，and manufacturing processes[J]. Journal of Dynamics，Monitoring and Diagnostics，2023，2(2)：69-88.
[124] GONG Z，CHEN B K，LIU J，et al. Robotic probing of nanostructures inside scanning electron microscopy[J]. IEEE Transactions on Robotics，2014，30(3)：758-765.
[125] JIN Z，ZHANG Z，GU G X. Autonomous in-situ correction of fused deposition modeling printers using computer vision and deep learning[J]. Manufacturing Letters，2019，22：11-15.
[126] YANG L，JIANG J，JI F，et al. Machine learning for micro-and nanorobots[J]. Nature Machine Intelligence，2024，6：605-618.