Modeling and Characteristics of Magnetic Bead Velocity in Microfluidic Chip for Sample Extraction with Magnetic Separation

doi:10.3901/JME.2018.20.245

Abstract

Abstract: In order to improve the separation efficiency of the biomedical samples using magnetic beads, a new magnetic separation microfluidic chip is proposed, which uses the combination of permanent magnet and soft magnet for the structure design of magnetic field. The velocity model for the motion of magnetic beads in the flow field is derived by the basic principles of magnetostatics and fluid mechanics. The motion of magnetic beads in the flow field is simulated transiently by a multiphysics-coupling simulation software. The relationship between the structure and position of soft magnetic elements on the horizontal velocity and vertical velocity of magnetic beads in microchannels is analyzed. The maximum allowable flow rate in the microchannel is calculated when the magnetic beads are completely adsorbed by different design structures. The results show that the thickness increasing of the soft magnet can rapidly reduce the horizontal speed of the magnetic bead, and reduce its fluctuation in the vertical direction. In addition, the larger the distance between the two soft magnets, the bigger the fluctuation in the horizontal and vertical directions. The smaller the distance, the shorter the time required for the magnetic bead particles to stabilize.

Key words: coupling field, magnetic Beads, microfluidic, soft magnet, velocity characteristics

CLC Number:

TG156

GU Jialiu, ZHU Yunfeng, LI Songjing. Modeling and Characteristics of Magnetic Bead Velocity in Microfluidic Chip for Sample Extraction with Magnetic Separation[J]. Journal of Mechanical Engineering, 2018, 54(20): 245-250.

References

[1] ALNAIMAT F,DAGHER S,MATHEW B,et al. Microfluidics based magnetophoresis:A review[J]. Chem. Rec.,2018(18):1-18.
[2] ZHOU Ran,WANG Cheng. Microfluidic separation of magnetic particles with soft magnetic microstructures[J]. Microfluid Nanofluid,2016(20):48.
[3] SHOJI S,KAWAI K. Flow control methods and devices in micrometer scale channels[J]. Topics in Current Chemistry,2011(304):1-25.
[4] ANTFOLK M,LAURELL T. Continuous flow microfluidic separation and processing of rare cells and bioparticles found in blood[J]. Analytica Chimica Acta,2017(965):1-27.
[5] YUNG C C,CHEN M W,SHIH H L. Particles sorting in micro channel using designed micro electromagnets of magnetic field gradient[J]. Journal of Magnetism and Magnetic Materials,2016(407):209-217.
[6] PAMME N,WILHELM C. Continuous sorting of magnetic cells via on-chip free-flow magnetophoresis[J]. Lab on a Chip,2006(6):974-980.
[7] GÓMEZ-PASTORA J,XUE Xiaozheng,KARAMPELAS I H,et al. Analysis of separators for magnetic beads recovery:From large systems to multifunctional microdevices[J]. Separation and Purification Technology, 2017(172):16-31.
[8] WU Jie,YAN Qifan,XUAN Shouhu,et al. Size-selective separation of magnetic nanospheres in a microfluidic channel[J]. Science Microfluid Nanofluid,2017(21):47.
[9] KHASHAN S A,DAGHER S,ALAZZAM A. Microfluidic multi-target sorting by magnetic repulsion[J]. Microfluidics and Nanofluidics,2018(22):64.
[10] GUSENBAUER M,SCHREFL T. Simulation of magnetic particles in microfluidic channels[J]. Journal of Magnetism and Magnetic Materials,2018(446):185-191.
[11] BANERJEE U,BIT P,GANGULY R,et al. Aggregation dynamics of particles in a microchannel due to an applied magnetic field[J]. Microfluid Nanofluid,2012(13):565-577.
[12] CAO Quanliang,LI Zhenhao,WANG Zhen,et al. Disaggregation and separation dynamics of magnetic particles in a microfluidic flow under an alternating gradient magnetic field[J]. J. Phys. D:Appl. Phys.,2018(51):195002.
[13] ZHOU Ran,YANG Qingbo,BAI Feng,et al. Fabrication and integration of microscale permanent magnets for particle separation in microfluidics[J]. Microfluid Nanofluid,2016(20):110.

[1]	HU Qiong, XIAO Yang, LU Di, CAO Zhikang, WANG Xiaolei, WANG Yan, WU Yang, HE Yiming. Influence of Microchannel Interface Shear on Cavitation Flow Field Characteristics of Liquid Film Seal [J]. Journal of Mechanical Engineering, 2023, 59(9): 171-185.
[2]	WANG Cheng-jie, YU Shuang, BAI Chen-chao, YANG Chao-xu, ZHANG Hong-peng, WANG Shuai, SUN Yu-qing, LI Guo-bin. Research on a High Sensitivity Hydraulic Oil Contaminant Detection Sensor [J]. Journal of Mechanical Engineering, 2023, 59(8): 42-49.
[3]	YANG Wenzhen, LIU Yu, LIU Rui, XIE Jin, XIONG Zhuang, TANG Bin, XU Kang. Preparation of Lyophobic Surface via Etching-phase Separation Method for Improving Threshold Performance of Microfluidic Inertial Switch [J]. Journal of Mechanical Engineering, 2023, 59(18): 349-356.
[4]	BAI Chenzhao, WANG Chengjie, WANG Xiaotian, YU Shuang, ZHANG Hongpeng, LI Wei, SUN Yuqing, LI Guobin. Research on Inductive Oil Contaminant Detection Sensor Based on High Gradient Magnetic Field Structure [J]. Journal of Mechanical Engineering, 2022, 58(23): 98-105.
[5]	LI Chen, YUAN Mu, XU Qingduo, GE Jiangqin, LI Zhian. Study on the Motion Characteristics of Solid Particles in Fine FlowChannel by Ultrasonic Cavitation [J]. Journal of Mechanical Engineering, 2022, 58(23): 218-226.
[6]	LU Yanjun, LIU Bo, CHEN Fumin, GUO Mingrong, TANG Heng, LUO Hexi. Precision Milling and Grinding of Mold Core for Microfluidic Chip and its Micro-injection Molding Technology [J]. Journal of Mechanical Engineering, 2022, 58(1): 244-255.
[7]	HE Pei, HUO Ziyao, HE Jiankang, FENG Fan, ZHU Zicai, LI Dichen. Biomimetic Ionic Gel battery Based on Multi-material Printing [J]. Journal of Mechanical Engineering, 2021, 57(5): 196-204.
[8]	SHI Haotian, ZHANG Hongpeng, GU Changzhi, MA Laihao, LI Guobin. Inductance-capacitance Dual Mode Sensor for the Detection of Contaminants in Hydraulic Oil [J]. Journal of Mechanical Engineering, 2020, 56(2): 20-26.
[9]	MA Laihao, ZHANG Hongpeng, XU Zhiwei, QIAO Weiliang, CHEN Haiquan. Research on Multi-functional Detection Model and Sensitivity of Opposed Solenoid Coil [J]. Journal of Mechanical Engineering, 2020, 56(13): 60-66.
[10]	ZENG Lin, ZHANG Hongpeng, TENG Huaibo, ZHANG Xingming. Novel Method for the Detection of Multi-contaminants in Marine Lubricants [J]. Journal of Mechanical Engineering, 2018, 54(12): 125-132.
[11]	YAN Zizi, LI Shanshan, LI Minghao, ZHANG Minghang, LI Tiejun, DAI Shijie. Influence of AC Electrothermal Flow on the Dielctrophoretic Behaviors of Micro-nano Particles [J]. Journal of Mechanical Engineering, 2017, 53(14): 202-208.
[12]	Guo Liang,Zheng Junna. Analysis of the Temperature Field and Force Ripple of a Double-Sided Tubular Permanent Magnet Generator [J]. Journal of Electrical Engineering, 2016, 11(3): 21-27.
[13]	WANG Qikun, WANG Hao. Behavior for Inertial Lift on Elastic Particles in Micro-channel [J]. Journal of Mechanical Engineering, 2015, 51(14): 160-166.
[14]	ZHANG Qin, XU Chenying, HUANG Weijun, AOYAMA Hisayuki. Microfluidic-based Tapping and Displacement of Micro ParticlesMicrofluidic-based Tapping and Displacement of Micro Particles [J]. Journal of Mechanical Engineering, 2015, 51(14): 199-205.
[15]	LIU Zhaomiao;LIU Likun;SHEN Feng. Numerical Analysis on Two-phase Flow Characteristics at Convection Microfluidic Y-junctions [J]. , 2014, 50(8): 189-196.