The 3D Printing Process and Forming System for Regenerated Scaffold Containing Microchannel Network and the Experimental Research

doi:10.3901/JME.2015.21.137

Abstract

Abstract:

3D printing technology has unique advantages and potential in the fabrication of artificial tissues and organs. However, there are still technological barriers in building artificial tissues with good metabolic performance. Based on the advantages of 3D printing technology, and adopting the features of the reaction forming of biomaterials, a new 3D printing process is proposed, in which hollow fibers can be formed directly, thus leading to the successful fabricating of the scaffolds containing microchannel network through three dimensional laminated manufacturing. By using dieless drawing theory, the deformation of hollow fiber size caused as a consequence of the drawing during the process of fabricating scaffold is quantitatively analyzed, which will then lays a well theoretical foundation for process optimization and parameter control. Besides, after the explaining of the key components and techniques for constructing the new 3D printing system, the experiments for fabricating, testing and analyzing scaffolds are then proceeded. The results show that the proposed new 3D printing process and system have good application potentials, and will surely provide a new technological approach for effectively solving the vascularization problem of artificial regenerated tissues.

Key words: microchannel network, regeneration scaffolds, 3D printing forming process

LIU Yuanyuan, LIANG Gang, LI Yu, ZHANG Yanan, LI Shuai, HU Qingxi.

The 3D Printing Process and Forming System for Regenerated Scaffold Containing Microchannel Network and the Experimental Research

[J]. Journal of Mechanical Engineering, 2015, 51(21): 137-147.

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