• CN:11-2187/TH
  • ISSN:0577-6686

机械工程学报 ›› 2018, Vol. 54 ›› Issue (23): 121-125.doi: 10.3901/JME.2018.23.121

• 数字化设计与制造 • 上一篇    下一篇

大尺寸个体化PEEK植入物精准设计与控性定制研究

李涤尘1,2, 杨春成1,2, 康建峰1,2, 王玲1,2, 黄立军3, 王磊3, 曹毅1,2, 石长全1,2, 连芩1,2   

  1. 1. 西安交通大学机械制造系统工程国家重点实验室 西安 710054;
    2. 陕西省快速制造技术工程技术研究中心 西安 710049;
    3. 空军军医大学第二附属医院 西安 710038
  • 收稿日期:2018-07-18 修回日期:2018-09-30 出版日期:2018-12-05 发布日期:2018-12-05
  • 作者简介:李涤尘,男,1964年出生,博士,长江学者特聘教授,西安交通大学机械制造系统工程国家重点实验室主任,博士研究生导师。主要研究方向为增材制造与生物制造。E-mail:dcli@mail.xjtu.edu.cn
  • 基金资助:
    国家自然科学基金重点项目(51835010)与西安交通大学新兴学科培育与学科交叉资助项目。

Precision Design and Control-performance Manufacturing Research of Large-size Individualized PEEK Implants

LI Dichen1,2, YANG Chuncheng1,2, KANG Jianfeng1,2, WANG Ling1,2, HUANG Lijun3, WANG Lei3, CAO Yi1,2, SHI Changquan1,2, LIAN Qin1,2   

  1. 1. State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049;
    2. Shaanxi Engineering Research Center for Rapid Manufacturing Technology, Xi'an 710049;
    3. Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038
  • Received:2018-07-18 Revised:2018-09-30 Online:2018-12-05 Published:2018-12-05

摘要: 我国每年有98%的骨缺损患者由于缺乏理想的人工植入物而成为功能受限者,个体化植入物设计制造已经成为我国从经验医疗转型精准医疗的关键部分。聚醚醚酮(Poly-ether-ether-ketone,PEEK)材料被普遍认为是目前最为理想的个体化植入物原材料之一,然而个体化PEEK植入物的复杂结构(尤其是大尺寸植入物)需要综合考虑PEEK材料性能、制造方法的工艺特性、临床植入应用环境等多方面的交叉影响。介绍了面向大尺寸个体化PEEK植入物的精准设计方法与控性定制3D打印方法,确立了个体化植入物设计方法与制造技术的几点准则,并描述了研究技术在一例大范围胸骨肿瘤治疗上的应用过程,所设计与制造的PEEK材料一体式胸肋骨假体,最终植入患者体内,协助大尺寸缺损胸壁的重建。

关键词: 3D打印, PEEK材料, 精准设计, 控性定制, 医疗临床

Abstract: Every year, 98% of patients in China become functionally restricted due to the lack of ideal individualized artificial implants. The design and manufacture methods of individualized implants has become a key factor of China's transformation from experience medicine to precision medicine. Poly-ether-ether-ketone (PEEK) material is generally considered to be one of the most ideal materials for individual implants at present. However, PEEK's special properties, manufacturing process characteristics, and clinical application environment should be considered to build the complex structure of individual PEEK implants (especially large scale implants). Therefore, a precision design method and a control-performance 3d printing method are put forward for the individualized PEEK implants, which established some guiding principles of design and manufacturing process. A case about extensive chest wall repaired by a large-size individualized PEEK implant is described to show the specific process of the precision design and control-performance manufacturing method.

Key words: 3D printing, clinical application, control-performance manufacturing, PEEK material, precision design

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