• CN:11-2187/TH
  • ISSN:0577-6686

机械工程学报 ›› 2015, Vol. 51 ›› Issue (14): 199-205.doi: 10.3901/JME.2015.14.199

• 交叉与前沿 • 上一篇    下一篇

基于微流体的微粒捕获与移动

张勤1, 徐晨影1, 黄维军1, 青山尚之2   

  1. 1.华南理工大学机械与汽车工程学院 广州 510640
    2.电气通信大学机械工程与智能系统系 东京 182-8585 日本
  • 出版日期:2015-07-20 发布日期:2015-07-20

Microfluidic-based Tapping and Displacement of Micro ParticlesMicrofluidic-based Tapping and Displacement of Micro Particles

ZHANG Qin1, XU Chenying1, HUANG Weijun1, AOYAMA Hisayuki2   

  1. 1.School of Mechanical & Automotive Engineering, South China University of Technology, Guangzhou 510640
    2.Department of Mechanical Engineering & Intelligence Systems, University of Electro-Communications, Tokyo 182-8585, Japan
  • Online:2015-07-20 Published:2015-07-20
  • Supported by:
    上海市科学技术委员会资助项目(13DZ1101504)

摘要: 微粒的捕获与移动广泛应用在生物工程、医药、微装配、化学分析、材料性能评定等各个领域。基于微流体提出一种新型微粒捕获与移动方法:通过对向放置在微粒两端的微管,向微粒喷射流体,形成流场;利用流场在微粒表面形成的压力包容面来捕获﹑挟持微粒,实现微粒的捕获与移动。以微米级微粒为例,详细分析微粒捕获与移动原理,通过仿真讨论颗粒捕获和把持的流场条件,解析微流体捕获、移动颗粒的动态过程,并通过试验证明建立模型的正确性和提出方法的可行性。研究和试验结果表明,通过两支微管对向喷射流体可以捕获和移动微粒。根据微粒的大小,溶液的黏度等参数,合理匹配流场参数,提出的方法可以捕获和移动任意尺寸的微粒,并可以使其按照微管移动方向,控制微粒做定向、定量运动,实现无接触地微粒的位置控制。

关键词: 非接触式, 微粒捕获与移动, 微流体, 显微操作

Abstract: Trapping and displacement of micro particles is extensively used in bioengineering, pharmaceuticals, micro-assembly, chemical analysis, and material performance evaluation. A microfluidic-based method for trapping and displacement of micro particles is presented. With this method, two identical microtubes are symmetrically aligned on both sides of a particle, which squirt inside fluid to produce a flow field. The particle is enveloped by a pressure surface which enables trapping and clamping the particle. This method is valid for micron-sized particles of arbitrary shapes and sizes. With micron-scale particles as examples, the mechanism of trapping and displacement is analyzed in detail, suitable fluid conditions of trapping and clamping particles are discussed through simulation, and dynamic process of trapping and displacement is analyzed. In addition, the feasibility of this method is verified by experiments. The results show that using a pair of aligned microtubes squirting fluid can trap and move micro particles. According to the particle size and fluid viscosity, micro particles of arbitrary sizes can be trapped and fixed with proper flow field parameters. This method is also capable of displacing the particle to some distance in a certain direction with the microtubes, thereby enabling noncontact position control of micro particles.

Key words: micro particle trapping and displacement, microfluidics, micromanipulation, noncontact

中图分类号: